Cholesterol Lowering Agent - Lipitor

Cholesterol Lowering Agent - Lipitor

Clinically tested in the United States. Lipitor has been successful at reducing low-density lipoproteins, and triglycerides (a form of lipid) in patients with high cholesterol.

Lipitor works by inhibiting a liver enzyme, HMG-CoA reductase which is the rate limiting step for cholesterol synthesis. When the liver is unable to produce sufficient quantities of its own cholesterol, it becomes dependent on the LDL-cholesterol (bad cholesterol) in the bloodstream. Through a process involving specific cell surface receptors called LDL receptors, LDL-cholesterol is efficiently cleared from the bloodstream, thereby potentially reducing the amount of cholesterol in the bloodstream.

What Lipitor does then, is that it not only increases the removal of LDL-cholesterol from the blood, it also reduces the synthesis, and secretion of LDL, and a very low density lipoprotein. Thus, by modifying, and reducing the right "right" type of lipoprotein, Lipitor effectively reduces LDL-cholesterol, and plasma triglycerides in the blood.

Lipitor should not be used by those know to be hypersensitive to any component of this agent. Side effects include mild, and transient forms of constipation, and abdominal pain. Patients with active liver disease or unexplained persistent elevations of serum transaminases, and/ or are pregnant should not take Lipitor.

Statins should be taken at night for cholesterol lowering. Why ?

Our liver synthesizes more cholesterol in the evening and at night. Hence, statin tablets have a better effect at lowering total and LDL cholesterol when taken at night, as shown in most studies. However, long-acting statins such as atorvastatin (Lipitor) and resuvastatin (Crestor) can be taken at anytime in the day because they stay in your body longer than other statins.

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