tested in the United States. Lipitor has been successful at reducing
low-density lipoproteins, and triglycerides (a form of lipid) in
patients with high cholesterol.
by inhibiting a liver enzyme, HMG-CoA reductase which is the rate
limiting step for cholesterol synthesis. When the liver is unable to
produce sufficient quantities of its own cholesterol, it becomes
dependent on the LDL-cholesterol (bad cholesterol) in the bloodstream.
Through a process involving specific cell surface receptors called LDL
receptors, LDL-cholesterol is efficiently cleared from the bloodstream,
thereby potentially reducing the amount of cholesterol in the
does then, is that it not only increases the removal of LDL-cholesterol
from the blood, it also reduces the synthesis, and secretion of LDL, and
a very low density lipoprotein. Thus, by modifying, and reducing the
right "right" type of lipoprotein, Lipitor effectively reduces LDL-cholesterol,
and plasma triglycerides in the blood.
should not be used by those know to be hypersensitive to any component
of this agent. Side effects include mild, and transient forms of
constipation, and abdominal pain. Patients with active liver disease or
unexplained persistent elevations of serum transaminases, and/ or are
pregnant should not take Lipitor.
should be taken at night for cholesterol lowering. Why ?
synthesizes more cholesterol in the evening and at night. Hence, statin
tablets have a better effect at lowering total and LDL cholesterol when
taken at night, as shown in most studies. However, long-acting statins
such as atorvastatin (Lipitor) and resuvastatin (Crestor) can be taken
at anytime in the day because they stay in your body longer than other
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